The 401 westbound in Chatham-Kent will be closed until 10am because of a crash.
Around 4:30am, the OPP responded to a single-vehicle crash involving a tractor trailer near Communication Rd.
Police says the driver of the tractor trailer lost control, flipped on to its side and skidded about 500m across the westbound lanes before coming to rest in the centre median.
No one was hurt.
A 34-year-old man is charged with careless driving.
The highway will be closed to allow tow operators to remove the vehicle.