One driver was pronounced dead at the scene and the other was taken to hospital with serious but non-life-threatening injuries after a late-night crash in Leamington.
The two-vehicle accident happened around 11pm on Talbot Rd. E between County Rd. 37 and Mersea Rd. 21, according to OPP.
The roadway was closed for several hours as police investigated, it re-opened just before 8am.
Police say neither driver had a passengerĀ in the vehicle.