Tyler Collins homered twice to power the Tigers to a 5-4 win over the Orioles at Comerica Park.
His three-run shot in the fifth inning erased a 4-2 deficit and Detroit held on from there.
Ian Kinsler also singled in a run for the Tigers.
Michael Fulmer moved to 5-and-1 with the win and Justin Wilson struck out Manny Machado with two on in the ninth to end it. Ubaldo Jimenez took the loss.