Niko Goodrum went 4-for-4 with a home run and JaCoby Jones added an inside-the-park homer as the Tigers topped the White Sox 5-1 in Detroit.
Jeimer Candelario doubled and tripled as the Tigers won their fourth straight game.
Daniel Norris got the win with two shutout innings of relief as Detroit improved to 9-and-5.
Dallas Keuchel gave up three runs in six frames to fall to 2-and-2 with the loss.
Danny Mendick had three hits and Adam Engel drove in the lone run for Chicago, which has lost five-of-six to slip to 8-and-9.
Major League Baseball has postponed Thursday's Tigers and Cardinals doubleheader as St. Louis continues to deal with Covid-19.
The twin-bill scheduled at Comerica Park was supposed to be a makeup of last week's postponement.
Due to the outbreak, the Cardinals have played only five games since the season began three weeks ago.
with files from Associated Press