Francisco Lindor doubled and homered as the Indians folded the Tigers 9-3 in Detroit.
Lindor launched a solo shot in the first inning and added a two-run double in the second.
Jose Ramirez also went deep and Jason Kipnis tagged a two-run single for Cleveland. Trevor Bauer fired seven innings of two-run ball to pick up the win.
Michael Fulmer gave up eight hits and six earned runs to take the loss for Detroit.
Nick Castellanos plated two runs in defeat. The Tigers dropped to 4-and-8.
Detroit begins a ten-game homestand as they start a three-game series against the New York Yankees tonight.
Mike Fiers goes to the mound for the Tigers and Jordan Montgomery takes the hill for the Yankees in the opener.