A late-inning rally came up short as the Tigers lost to the San Francisco Giants 5-4 at Comerica Park.
Detroit scored four times in the seventh, with Victor Martinez singling in two runs and Ian Kinsler and Nicholas Castellanos each getting an RBI.
Hunter Pence drove in three runs and gave the Giants a five-run lead with a two-run triple in the fourth inning.
Ty Blach tossed six-plus innings of three-run ball to earn the win. Sam Dyson picked up his third save.
Daniel Norris was charged with the loss, giving up five runs in four innings to fall to 4-and-7.
In this afternoon's rubber match, Anibal Sanchez gets the start for Detroit, while Johnny Cueto goes to the mound for San Francisco.