Jorge Bonifacio, Niko Goodrum and Grayson Greiner all homered as the Tigers topped Cleveland 7-4.
Miguel Cabrera drove in a pair of runs for Detroit, which took two-of-three in the series following a nine-game losing streak.
The Tigers second win in the three-game series came after losing their previous 20 games to Cleveland.
Daniel Norris picked up the win and Jose Cisnero notched his first save.
Carlos Carrasco yielded four runs in less than four frames as he fell to 2-and-3 with the loss.
With files from MetroSource