The Twins reeled off eight runs in the eighth inning as they rallied past the Tigers, 10-4, in Detroit.
Zack Granite clubbed a three-run homer to cap the frame for Minnesota.
Six Detroit relievers combined to give up seven hits and eight runs, with Daniel Stumpf taking the loss.
Detroit pitcher Alex Wilson broke his right fibula in the eighth inning when hit by Joe Mauer's line drive.
The Tigers are on a six-game slide.