Grayson Greiner went 2-for-4 with three RBI as the Tigers topped the White Sox 8-3 in Chicago.
Dawel Lugo had a two-run double and Mikie Mahtook added a two-run homer for Detroit.
The Tigers built a 6-0 lead in the third inning and cruised from there.
Francisco Liriano got the win.
Detroit is 3-and-8 in its last 11 games.
In tonight's rubber game, Jordan Zimmermann gets the nod for Detroit while Chicago counters with Michael Kopech.