Ben Roethlisberger threw for 299 yards and four touchdowns as the Steelers crushed the Titans 40-17 on "Thursday Night Football" at Heinz Field.
Antonio Brown hauled in three of the TDs, catching 10 passes total for 144 yards.
Pittsburgh has won five straight to move to 8-and-2. The Steelers are a half-game ahead of the Patriots for the best record in the AFC.
The Titans fell a half-game behind the Jaguars for first in the AFC South.
Marcus Mariota was intercepted four times to put Tennessee behind four-to-nothing in the turnover battle. The Titans fell to 6-and-4.