Logan Couture scored the only goal of the shootout, giving the Sharks a 3-2 victory over the Maple Leafs in Toronto.
San Jose's Justin Braun and Joe Pavelski scored 2:07 apart in the third to force extra time while Matt Jones made 29 saves for the Sharks, who have won their last two games.
Leafs rookie centre Auston Matthews netted his 13th goal for Toronto, which has dropped eight of its last 11.
Frederik Andersen made 40 saves in the loss.