The Red Wings doubled up the Blackhawks 4-2 in preseason play at Little Caesars Arena.
Thomas Vanek scored on the power play in the first period, Andreas Athanasiou, Evgeny Svechnikov and Gustav Nyquist also lit the lamp for Detroit.
Goalie Jonathan Bernier stopped 11 of the 13 shots he faced and netminder Patrik Rybar turned aside all 10 shots on goal in the win.
The Wings host the Boston Bruins tomorrow.