Mitch Moreland drove in four runs including a three-run home run in the 10th inning as the Boston Red Sox defeated the Blue Jays 10-7.
J.D. Martinez also drove in four runs including a three-run homer in the eighth inning.
Devon Travis and Justin Smoak had homers for Toronto (52-60).
Ken Giles (0-3) earned the loss after surrendering five runs in the 10th.
Craig Kimbrel (3-1) picked up the win after blowing a save situation with the Blue Jays up 5-4 in the ninth.
Toronto's (51-61) bullpen spoiled a dominant pitching performance from starter Marcus Stroman.