The Raptors kept pace as Delon Wright led their balanced attack with 15 points in a 101-86 win against the Grizzlies.
DeMar DeRozan and Fred VanVleet each scored 13 for Toronto, which opened the final period with a 12-4 run to take an 88-78 lead.
The Raptors improved to a league-best 21-4 at home despite shooting 6-for-35 from 3-point range.
DeMar DeRozan added 13 points and Jonas Valanciunas chipped in with 12 points, nine rebounds and three assists.