Kawhi Leonard poured in a game-high 35 points to lead the Raptors to a 112-105 win over the Timberwolves in Toronto.
Jonas Valanciunas posted 16 points and nine rebounds off the bench as the Raptors improved to 5-and-0 on the NBA season.
Kyle Lowry added 13 points and 10 assists in the victory.
Jimmy Butler netted 23 points to pace Minnesota, which slipped to 2-and-3 with all three losses on the road.
Derrick Rose had 16 points off the pine in defeat.