Kawhi Leonard scored 36 points to lift the league-leading Raptors to a 113-102 victory over Jimmy Butler and the new-look Sixers, Toronto's 13th consecutive win over Philadelphia at home.
Jonas Valanciunas scored a season-high 26 points, while Serge Ibaka had 18 for the Raptors (21-5).
Leonard connected on a season-high 5-for-6 from three-point range.
Butler had 38 points to lead Philly (17-9), while JJ Redick added 25.