The New Orleans Pelicans ended Toronto's perfect NBA record at home, downing the Raptors 126-110.
E'Twaun Moore had a season-high 30 points for the Pelicans (7-6) while Jrue Holiday tied a season-high with 29 and Anthony Davis had 25.
Pascal Siakam led Toronto (12-2) with 22 points while Kawhi Leonard had 20 and Serge Ibaka 19.
Kyle Lowry had just four points on 1-of-9 shooting. Toronto shot just 40.2 per cent from the floor and hit just 13-of-45 three-pointers.
The Raptors came into the game riding a six-game winning streak and boasting the league's best record.
The Raptors had won all seven previous home games.
Going into Monday's play, Toronto, Memphis and Milwaukee were the only remaining unbeaten teams at home.