Pekka Rinne made 18 saves for his third shutout of the season and the 54th of his career as the Nashville Predators blanked the Maple Leafs 4-0.
Rinne is now tied with Marc-Andre Fleury, Bernie Parent and Ed Giacomin for 21st on the NHL's all-time shutout list.
Mattias Ekholm, Kevin Fiala and Colton Sissons each had goal and an assist for Nashville (26-15-3), while P.K. Subban also scored.
Michael Hutchinson stopped 28 shots for Toronto (27-13-2), which hit three posts and also had a goal called back for offside.
The Leafs were coming off one of their most complete performances of the season in Saturday's 5-0 shutout of the Vancouver Canucks, but have now lost three of their last four.