Rafael Nadal split his first two sets with Nick Kyrgios before winning a pair of tiebreakers to advance at Wimbledon in England.
Eight-time champ and third seed Roger Federer beat British wild-card entry Jay Clarke 6-1, 7-6, 6-2.
Eighth seed Kei Nishikori won his second-round match, as did unseeded Americans Sam Querrey, Steve Johnson and Tennys Sandgren.
Former Wimbledon finalist Milos Raonic faces American Reilly Opelka Friday.
Raonic, the No. 15 seed from beat Robin Haase of the Netherlands on Wednesday, marking the Canadian's second straight-sets win in a row.
Eighteen-year-old Felix Auger-Aliassime will play Frenchman Ugo Humbert in the third round at Wimbledon.
Auger-Aliassime, the No. 19 seed from Montreal, defeated France's Corentin Moutet in a four-set win on Wednesday.