Windsor fire crews responded around 10 a.m. Friday to a home in the 4000 block of Manzanillo Crescent.
Investigators say the fire started in a bedroom of the raised ranch house.
Damage is estimated at $150,000. No one was home at the time, and there were no injuries.
Four people are displaced, and two cats are unaccounted for.
Investigators are still working to determine the cause.