Marcus Mariota threw a pair of third-quarter touchdown passes to put the Titans ahead for good in a 33-27 win over the Seahawks at Nissan Stadium.
DeMarco Murray had 14 carries for 115 yards and a touchdown as Tennessee improved to 2-and-1.
Russell Wilson threw for 373 yards and four touchdowns passes for Seattle, which fell to 0-and-2 on the road and 1-and-2 overall.
Doug Baldwin caught 10 passes for 105 yards and a touchdown in defeat.
LaSalle's Luke Willson had three catches for 53 yards, including a 27 yard touchdown reception.