Antti Raanta made 26 saves as the Arizona Coyotes halted the Maple Leafs' win streak at six games with a 4-1 victory.
Brendan Perlini, Oliver Ekman-Larsson, Max Domi and Tobias Rieder scored for the Coyotes (5-15-3), who have won three in a row for the first time this season.
Rookie Clayton Keller, a former Spitfire draft choice picked up two assists to give him 20 points in 23 games.
James van Riemsdyk scored for the Maple Leafs (14-8-0).
Frederik Andersen had his shutout streak snapped at 1:41:28 with a first-period goal against after blanking the opponent in back-to-back games. He finished the game with 28 saves.
Toronto's Auston Matthews, playing in his 100th career game, looked to have tied the game 2-2 with 3:50 to play only for the goal to be overturned upon review for goalie interference on Zach Hyman.