Connor Brown set a career-high with four points and Mitch Marner scored another impressive goal as the Leafs spoiled James Reimer's return to the A.C.C.
Brown scored two goals and added two assists in the 6-1 win over Reimer's Florida Panthers (8-8-1).
Leo Komarov, James van Riemsdyk and Jake Gardiner also added tallies in Toronto's seventh victory in nine tries at home (7-2-0),
Frederik Andersen stopped 27 shots, improving to 6-2-0 in November for Toronto (8-6-3).
Aaron Ekblad scored the lone goal for Florida.
Ekblad will be in Windsor this weekend for Hometown Hockey.