Russell Wilson threw two touchdowns and ran for another as the Seahawks knocked off the 49ers, 24-13, at Levi's Stadium.
Wilson's second TD-pass early in the fourth quarter to put Seattle up by 15 effectively capped the game.
Wilson overcame an interception as the Seahawks improved to 7-and-4.
They're still one game behind the 8-and-3 Rams in the NFC West.
The Seahawks lost tight end Luke Willson in that game.
The LaSalle-native was forced out with a concussion and is being evaluated.
Willson has has managed 11 receptions for 106 yards and three touchdowns through 10 games.