The NFL's Thanksgiving tripleheader kicks off in Detroit as the last-place Lions host the first-place Bears in an NFC North matchup at Ford Field.
Running back Kerryon Johnson and wide receiver Marvin Jones Jr. will not play because of knee injuries.
Defensive end Ziggy Ansah, defensive tackle A'Shawn Robinson and corner Darius Slay are also questionable today with injuries.
Chicago starting quarterback Mitchell Trubisky is listed as doubtful with a shoulder injury.
Detroit snapped a three-game skid with a 20-19 home win over Carolina on Sunday. The Lions are 4-and-6 on the season.
The Bears are riding a four-game winning streak that has them on top of the division at 7-and-3.
Chicago just beat Detroit 34-22 at Soldier Field in Week 10.
Also on Thursday, the Washington Redskins visit the Dallas Cowboys and the night game has the New Orleans Saints playing host the Atlanta Falcons.