Jonas Valanciunas shined with 26 points and 17 rebounds as the Grizzlies rolled past the Pistons 96-82 in Memphis.
Dillon Brooks had 15 and Jaren Jackson added 14 for the Grizzlies, who have won five-of-six.
Andre Drummond put up 25 points and 18 rebounds for Detroit, which has dropped six-of-seven. Christian Wood and Langston Galloway each scored 17 off the bench in defeat.
Grizzlies head coach Taylor Jenkins says they bounced back in the second half.
The Pistons return to Little Caesars Arena to host the Phoenix Suns Wednesday.