Windsor firefighters were called to a home in Walkerville on Tuesday evening.
Crews responded to the 2000 block of Willistead Crescent shortly before 6 p.m. and found smoke coming from the attic of a two-storey house.
The fire was reported out over an hour later.
Early estimates of damage are pegged at $500,000.
Officials said no occupants were home at the time of the fire and no injuries were repored.
The investigation into the cause is ongoing.