Former Spitfire Cam Fowler scored on the power play in the third period to give the Ducks the lead and a 3-2 win against the Maple Leafs at Air Canada Centre.
It was Anaheim's second goal with a man advantage.
The first came from Ryan Getzlaf in the second period.
John Gibson stopped 33 shots as the Ducks have won five-of-seven.
Auston Matthews tallied his 15th and Nazem Kadri his 11th in the loss.
Toronto has lost seven-of-nine, but three of them were in shootouts.