Javier Baez homered twice and David Bote also went deep as the Cubs crushed the Tigers 9-3 in Detroit.
Each player finished 3-for-5, with Baez driving in three runs and Bote plating four in Monday's win.
The Cubs Alec Mills pitched seven innings for the win.
Tigers starter Casey Mize allowed four runs in three-and-a-third to take the loss in his second career start for Detroit.
Christin Stewart hit a two-run homer in defeat.
The three-game series continues tonight as Spencer Turnbull gets the start for the Tigers, while the Cubs counter with Tyler Chatwood.
First pitch is set for 7:10 p.m. at Comerica Park.
With files from MetroSource