Blue Jackets forward Gustav Nyquist scored the overtime winner on a penalty shot to lead Columbus to a 4-3 win over the Maple Leafs in Toronto.
The penalty shot was awarded after Mitch Marner hooked Nyquist on a breakaway.
Alexander Wennberg tied the game at three for Columbus with a power-play goal midway through the third.
Riley Nash and Pierre-Luc Dubois staked the Jackets to an early 2-0 lead before Toronto scored the next three.
Columbus snapped a two-game skid to improve to 4-3-and-2 on the NHL season.
Kasperi Kapanen, Auston Matthews and William Nylander lit the lamp for the Leafs, who have lost two of their last three.
The Maple Leafs hit the road to take on the Bruins Tuesday night in Boston.