Edwin Encarnacion hit a grand slam and drove in five runs to help the Indians crush the Tigers 12-2 in Cleveland.
Francisco Lindor and Jose Ramirez each had three hits, including a home run.
Jason Kipnis also went deep for Cleveland, which won its seventh straight.
Adam Plutko was the beneficiary of the offensive splurge to pick up the victory.
Matthew Boyd gave up a season-high six runs in three-plus innings to take the loss.
Niko Goodrum and James McCann drove in the Detroit runs.
The Tigers have lost five straight.
The Tigers are back at Comerica Park tonight to open a four-game series with the Athletics.
Jordan Zimmermann is slated to start for Detroit, while Oakland sends Edwin Jackson to the mound.