Roberto Perez's solo homer in the eighth inning was the difference in the Indians' 2-1 win over the Tigers at Progressive Field.
Jose Ramirez also had a solo shot for Cleveland, which has won the first two of the four-game series.
Josh Tomlin threw five shutout innings, but wasn't part of the decision.
Andrew Miller earned the win and Cody Allen nailed down his third save as Cleveland won its third straight.
Jeimer Candelario was 3-for-3 with an RBI double in the seventh to tie the game at one for Detroit.
Reliever Alex Wilson was charged with the loss, giving up the go-ahead run on a solo shot in the eighth.
Tonight, Jordan Zimmerman gets the nod for the Tigers and Carlos Carrasco takes the mound for the Indians.