Pierre-Luc Dubois scored in overtime as the Blue Jackets rallied from a three-goal deficit to beat the Red Wings 5-4 in Columbus.
Artemi Panarin scored on a power-play for Columbus with just over two minutes left in regulation to force overtime.
Cam Atkinson had two power-play goals and Seth Jones three assists for Columbus, which is 13-1-and-1 in its last 15 games.
Tyler Bertuzzi scored a pair of goals for Detroit while Henrik Zetterberg doled out three assists in the loss.
The Red Wings are 3-0-and-1 in their last four games.