Andrelton Simmons went 2-for-3 with a home run, two RBI and two runs scored to help the Angels defeat the Tigers 6-2 in Anaheim.
Eric Young Jr. added a solo blast to back five innings of one-run ball from Nick Tropeano.
Detroit took a 1-0 lead on a solo homer by Nicholas Castellanos in the first inning.
Los Angeles is still two games under .500 after losing six of its previous seven games.
Jose Iglesias singled in Detroit's other run in the sixth.
The Tigers have dropped four in a row to fall to 47-and-66.